Background
Structural biology is a fascinating discipline that has provided valuable insights into the three-dimensional structures of cells and macromolecules. Preparing samples for advanced techniques such as ATR-FTIR Spectroscopy, Crystallography, or Cryo-EM often requires diverse sample types and specific conditions to ensure optimal results.
Challenges
- Handling tiny volumes of precious samples on delicate structures, such as cryo-EM grids, requires precision and careful technique.
- Managing extreme conditions—e.g., maintaining very cold temperatures without interruptions—is crucial to ensuring vitrification in cryo-EM, which is necessary for forming amorphous ice crystals.
- Preparing different samples in different solvents can be challenging and requires specific setups for sample preparation.
Your Advantages of Using Microdispensing
- Ultra-low volume handling for precise dispensing onto substrates of any type.
- Non-contact dispensing ensures no interaction between the dispenser unit and the substrate, preventing surface damage.
- Temperature control capabilities allow equipment to be heated or cooled as needed.
- Seamless integration into existing setups for enhanced workflow efficiency.
Example applications of microdispening in structural biology
SAMPLE PREPARATION FOR ATR-FTIR SPECTROSCOPY
PROTEIN PREPARATION FOR CRYSTALLOGRAPHY
Microdrop-Clients & References
We choose Microdrop for its seamless integrability and precise temperature control, which enabled its successful integration into our EasyGrid platform for Cryo-EM sample preparation.
Gergerly Papp, EMBL
Customer Storys
Dies ist ein Typoblindtext. An ihm kann man sehen, ob alle Buchstaben da sind und wie sie aussehen. Manchmal benutzt man Worte wie Hamburgefonts, Rafgenduks oder Handgloves, um Schriften zu testen.
Dr. Markus Dummyprof, Universität Jena, Germany
Learn more
- Integratable Electronic Control System for Microdispensing
- Datasheet: Microdrop Heads (181.0 KiB)
- Datasheet: Autodrop Pipettes
- Datasheet: MD-E-5000